Never delete it directly, but you can compress it safely. WinSxS holds every version of Windows components (update rollback depends on it). Microsoft's official slimming command is the DISM component cleanup.
Why is WinSxS so large?
It stores multiple versions of every Windows component to support updates and rollback. It grows with every update; 10-15GB is normal.
Are third-party WinSxS cleaners safe?
Not recommended. DISM is the only Microsoft-supported method; brute-force deletion can corrupt the component store and break Windows Update permanently.